Glossary

The foundational elements of our technology

 

Companion imaging agent

Built using the same modular structure and targeting ligand as its matching small molecule drug conjugate (SMDC), it carries a small amount of radioactive material that can be seen with nuclear imaging.

Drug payload

The therapeutic agent carried by the SMDC and designed to be precisely delivered within the diseased cell. 

Nuclear imaging

Uses a small amount of a radionuclide to create a diagnostic image using a camera that detects radioactivity. 

Receptor-mediated endocytosis

The process by which cells engulf and absorb specific molecules that bind to receptors on the surface of the cell.

Small molecule drug conjugates (SMDC)

SDMCs are composed of a targeting ligand, a spacer/linker system, and a drug payload. 

Spacer/linker system

Connects the drug payload or companion imaging agent to the targeting ligand while it is circulating through the body. It releases the drug once inside the targeted diseased cell.

Targeting ligand

A molecule that binds to receptors on the diseased cell to which a super-potent drug or radionuclide can be attached.