EC2629 (folate receptor-targeted pro-PBD)
Delivers a potent DNA-reactive cytotoxic agent to folate receptor-positive cancer cells and TAMs
EC2629 is an investigational, proprietary folate receptor-targeted SMDC which utilizes a potent DNA-reactive cytotoxic agent to treat cancer. Strong anti-tumor effect has been observed preclinically in xenograft models safely treated with EC2629, including curative activity against triple negative breast cancer and drug-resistant ovarian cancer. EC2629 is unique in that it targets and eliminates both folate receptor positive cancer cells as well as the tumor-associated macrophages (TAMs) that reside within the tumor environment. Preclinical development of EC2629 is currently underway with a projected IND filing in 2017.